Pneumotox » Drug » All-transretinoic acid (ATRA) » X.ab - The differentiation- or ATRA syndrome

All-transretinoic acid (ATRA)

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X.ab The differentiation- or ATRA syndrome

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Includes fever, weight gain, peripheral edema, respiratory distress, interstitial pulmonary opacities, pleural and/or pericardial effusions, hypotension and renal failure. See also under IIb (ARDS) and Va

Last update : 20/11/2013

Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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