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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Aprotinin

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 01/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Vasopressin for treatment of shock following aprotinin administration.
Canadian journal of anaesthesia = Journal canadien d'anesthesie 2004 Feb;51;169-72 2004 Feb
Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies.
Anesthesiology 2001 Jul;95;64-71; discussion 5A-6A 2001 Jul

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