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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (early effects)

5

I.ab Radiation-induced lung injury (RILI)

5
Last update : 28/03/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (medium term & late effects)
5
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, stereotactic (SBRT)
5

Publications

Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2006 Jul;80;93-7 2006 Jul
Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta.
International journal of radiation oncology, biology, physics 2001 Jul 15;50;899-908 2001 Jul 15

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