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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Radiation therapy (early effects)
5
XV.f
Path: Diffuse alveolar damage (DAD-pattern) (see also IL)
2
Last update :
31/01/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
See also under
Radiation therapy (medium term & late effects)
Radiation therapy to the chest
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
Radiation therapy, stereotactic (SBRT)
Publications
The association of adult respiratory distress syndrome (ARDS) with thoracic irradiation (RT).
Low-dose radiation pneumonitis.
The hazard of acute radiation pneumonitis in children receiving mediastinal radiation.
Interstitial pneumonia; a pathologic concept.
Radiation pneumonitis; clinicopathological exercises.