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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Radiation therapy (early effects)
5
I.v
Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence
3
Last update :
23/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Radiation therapy (medium term & late effects)
Radiation therapy to the chest
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
Radiation therapy, stereotactic (SBRT)
Publications
Small airways function in breast cancer patients before and after radiotherapy.