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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Protamine

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 02/05/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

[Anaphylaxis to protamine during cardiovascular surgery].
Annales pharmaceutiques francaises 2014 May;72;143-5 2014 May
Anaphylaxis: a review of 601 cases.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2006 Jul;97;39-43 2006 Jul
Antibody formation after drug administration during cardiac surgery: parameters for aprotinin use.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1993;12;S26-33 1993
Anaphylactoid reactions to protamine: an often lethal complication in insulin-dependent diabetic patients undergoing vascular surgery.
Journal of vascular surgery 1989 Feb;9;342-50 1989 Feb
Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine.
The New England journal of medicine 1989 Apr 06;320;886-92 1989 Apr 06

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