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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 03/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.
Endocrinology and metabolism (Seoul, Korea) 2023 Apr;38;282-284 2023 Apr
Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.
Iranian Red Crescent medical journal 2016 Apr;18;e23320 2016 Apr
Propylthiouracil-induced alveolar hemorrhage.
European journal of rheumatology 2015 Sep;2;114-116 2015 Sep
Propylthiouracil-induced autoimmune disease.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2015 Aug;19;484-6 2015 Aug
Propylthiouracil induced pulmonary-renal syndrome: a case report.
Acta reumatologica portuguesa 2015;40;190-2 2015
A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy.
BMJ case reports 2014 Aug 22;2014; 2014 Aug 22
Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis and rheumatism 2012 Nov;64;3779-87 2012 Nov
Occult pulmonary hemorrhage as a rare presentation of propylthiouracil-induced vasculitis.
Pediatrics 2011 Jan;127;e245-9 2011 Jan
[Diffuse alveolar hemorrhage: Causes and outcomes in a referral center].
Reumatologia clinica 2010;6;196-8 2010
Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.
The American journal of the medical sciences 2009 Jun;337;470-2 2009 Jun
Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil.
Journal of internal medicine 2008 Dec;264;610-2 2008 Dec
Propylthiouracil-related diffuse alveolar hemorrhage with negative serologies and without capillaritis.
Respiratory medicine 2007 Apr;101;865-7 2007 Apr
A fatal case of propylthiouracil-induced ANCA-positive vasculitis.
MedGenMed : Medscape general medicine 2006 Oct 12;8;10 2006 Oct 12
Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).
Internal medicine (Tokyo, Japan) 2003 Jun;42;529-33 2003 Jun
Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment.
Journal of the American Society of Nephrology : JASN 2002 Feb;13;437-445 2002 Feb
Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.
Chest 1999 Nov;116;1485-8 1999 Nov
Wegener's granulomatosis in a patient receiving propylthiouracil for Graves' disease.
Seminars in arthritis and rheumatism 1998 Oct;28;124-9 1998 Oct
Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.
Chest 1992 Nov;102;1595-6 1992 Nov

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