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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

II.b ARDS - Acute lung injury

1
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.
Endocrinology and metabolism (Seoul, Korea) 2023 Apr;38;282-284 2023 Apr
Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.
Chest 1992 Nov;102;1595-6 1992 Nov
Recurrent adult respiratory distress-like syndrome associated with propylthiouracil therapy.
The European respiratory journal 1991 Jul;4;899-901 1991 Jul

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