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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

I.b Pneumonitis (ILD)

1
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Propylthiouracil-induced nonspecific interstitial pneumonia.
Chest 2011 Mar;139;687-690 2011 Mar
A man with interstitial pneumonia due to propylthiouracil.
Internal medicine (Tokyo, Japan) 2003 Oct;42;1026-30 2003 Oct
Propylthiouracil-induced diffuse interstitial pneumonitis.
Archives of internal medicine 1984 Sep;144;1764-5 1984 Sep

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