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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

VI.d Pulmonary vasculitis or capillaritis

1
Last update : 21/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis research & therapy 2013;15;R196 2013
Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.
The American journal of the medical sciences 2009 Jun;337;470-2 2009 Jun
Clinical and pathological features of renal involvement in propylthiouracil-associated ANCA-positive vasculitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 May;49;607-14 2007 May
Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.
Arthritis research & therapy 2005;7;R1072-81 2005
Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.
Chest 1999 Nov;116;1485-8 1999 Nov
Wegener's granulomatosis in a patient receiving propylthiouracil for Graves' disease.
Seminars in arthritis and rheumatism 1998 Oct;28;124-9 1998 Oct

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