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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

X.d Lupus - Lupus syndrome (see also Vd)

1
Last update : 21/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Propylthiouracil-induced autoimmune syndromes: 11 case report.
Rheumatology international 2012 Mar;32;679-81 2012 Mar
Propylthiouracil-induced lupus-like or vasculitis syndrome.
Multidisciplinary respiratory medicine 2012 Jul 17;7;14 2012 Jul 17
Propylthiouracil and antineutrophil cytoplasmic antibody associated vasculitis: the detective finds a clue.
Seminars in arthritis and rheumatism 2006 Aug;36;1-3 2006 Aug
Propylthiouracil-induced autoimmune syndromes: two distinct clinical presentations with different course and management.
Seminars in arthritis and rheumatism 2006 Aug;36;4-9 2006 Aug

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