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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

III.d Alveolar hemorrhage, diffuse (ANCA-positive/-related)

2
Last update : 30/03/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.
Iranian Red Crescent medical journal 2016 Apr;18;e23320 2016 Apr
Propylthiouracil-induced autoimmune disease.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2015 Aug;19;484-6 2015 Aug
The onset of antineutrophil cytoplasmic antibody-associated vasculitis immediately after methimazole was switched to propylthiouracil in a woman with Graves' disease who wished to become pregnant.
Endocrine journal 2013;60;383-8 2013
Propylthiouracil-induced lupus-like or vasculitis syndrome.
Multidisciplinary respiratory medicine 2012 Jul 17;7;14 2012 Jul 17
Alveolar hemorrhage in vasculitis: primary and secondary.
Seminars in respiratory and critical care medicine 2011 Jun;32;310-21 2011 Jun
Propylthiouracil-induced leucocytoclastic vasculitis with pulmonary hemorrhage treated with plasmapheresis.
The American journal of the medical sciences 2009 Jun;337;470-2 2009 Jun
Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil.
Journal of internal medicine 2008 Dec;264;610-2 2008 Dec
A fatal case of propylthiouracil-induced ANCA-positive vasculitis.
MedGenMed : Medscape general medicine 2006 Oct 12;8;10 2006 Oct 12
Diffuse alveolar hemorrhage associated with antineutrophil cytoplasmic antibody levels in a pregnant woman taking propylthiouracil.
The Korean journal of internal medicine 2006 Dec;21;240-3 2006 Dec
Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis.
Kidney international 2006 Apr;69;1477-81 2006 Apr
Pulmonary capillaritis with hemorrhage due to propylthiouracil therapy in a child.
Pediatric pulmonology 2005 Jan;39;88-92 2005 Jan
Antineutrophil cytoplasmic antibody positive alveolar haemorrhage during propylthiouracil therapy for hyperthyroidism.
Respirology (Carlton, Vic.) 2003 Dec;8;532-5 2003 Dec
Diffuse alveolar hemorrhage associated with myeloperoxidase-antineutrophil cytoplasmic antibody induced by propylthiouracil therapy.
Respiration; international review of thoracic diseases 2002;69;473 2002
Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.
Chest 1999 Nov;116;1485-8 1999 Nov
Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure.
Chest 1992 Nov;102;1595-6 1992 Nov

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