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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Propofol
3
X.f
Anaphylaxis-Anaphylactoid reaction (can be fatal)
2
Propofol anaphylaxis may be related to soybean in the vehicle (PMID 22211170)
Last update :
19/04/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Excipients-Vehicle-Preservatives (of drugs)
Soybean
Publications
Suspected anaphylactic reaction associated with microemulsion propofol during anesthesia induction.
Anaphylaxis after propofol infusion for Port-A-Cath insertion in a 35-year old man.