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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Procainamide

4

X.y Subclinical ANA positivity

1
Last update : 12/10/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

IgG antibodies to the histone complex H2A-H2B characterize procainamide-induced lupus.
Clinical immunology and immunopathology 1985 Jul;36;49-59 1985 Jul
Antinuclear antibody induced by procainamide. A prospective study.
The New England journal of medicine 1969 Jul 10;281;64-6 1969 Jul 10

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