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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Procainamide

4

X.d Lupus - Lupus syndrome (see also Vd)

2
Last update : 03/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Drug-induced lupus.
Toxicology 2005 Apr 15;209;135-47 2005 Apr 15
Serologic evaluation of patients receiving procainamide.
Arthritis and rheumatism 1992 Feb;35;219-23 1992 Feb
Serologic changes during induction of lupus-like disease by procainamide.
The American journal of medicine 1986 May;80;999-1002 1986 May
Antinuclear antibody induced by procainamide. A prospective study.
The New England journal of medicine 1969 Jul 10;281;64-6 1969 Jul 10
Reversible lupus-like illness induced by procainamide.
American heart journal 1966 Dec;72;806-8 1966 Dec
LUPUS-LIKE ILLNESS PRECIPITATED BY PROCAINAMIDE HYDROCHLORIDE.
JAMA 1965 May 10;192;444-7 1965 May 10
Procainamide-induced lupus erythematosus.
The New England journal of medicine 1962 Dec 27;267;1357-8 1962 Dec 27

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