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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Procainamide

4

XII.c Pericardial effusion (w/wo tamponade)

1
Last update : 03/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Isoniazid-induced lupus erythematosus presenting with cardiac tamponade.
American journal of therapeutics 2002;9;163-5 2002
Cardiac tamponade associated with drug-induced systemic lupus erythematosus.
Critical care medicine 1989 Sep;17;961-2 1989 Sep
Procainamide-induced lupus erythematosus pericarditis encountered during coronary bypass sugery.
The American journal of medicine 1980 Jul;69;159-62 1980 Jul
Pericardial tamponade. A presenting manifestation of procainamide-induced lupus erythematosus.
The American journal of medicine 1975 Apr;58;581-5 1975 Apr

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