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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Phenytoin (diphenylhydantoin)

4

VII.a Lymphadenopathy (intrathoracic)

2
Last update : 22/08/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Anticonvulsants
3

Publications

Dilantin-associated lymphadenopathy. Spectrum of histopathologic patterns.
The American journal of surgical pathology 1995 Jun;19;675-86 1995 Jun
Does prolonged use of diphenylhydantoin predispose to pulmonary sarcoidosis?
European neurology 1986;25;281-4 1986
Necrotizing vasculitis associated with diphenylhydantoin: two fatal cases.
Human pathology 1983 Feb;14;182-4 1983 Feb
Lymphadenopathy associated with diphenylhydantoin therapy.
Clinical oncology 1982 Dec;8;351-6 1982 Dec
[Lymphadenopathies and protein anomalies following phenylhydantoine therapy].
La Nouvelle presse medicale 1976 Apr 24;5;1125-7 1976 Apr 24

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