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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Phenytoin (diphenylhydantoin)

4

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 02/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Anticonvulsants
3

Publications

A case report of phenytoin-induced eosinophilic pneumonia.
Respiratory medicine case reports 2019;28;100922 2019
Diphenylhydantoin (phenytoin)-induced chronic pulmonary disease.
Lung India : official organ of Indian Chest Society 2009 Oct;26;155-8 2009 Oct
Diagnosis and management of drug-associated interstitial lung disease.
British journal of cancer 2004 Aug;91 Suppl 2;S24-30 2004 Aug
Phenytoin-related immunodeficiency associated with Loeffler's syndrome.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1995 Jun;74;479-82 1995 Jun
Phenytoin-induced acute respiratory failure with pulmonary eosinophilia.
The American journal of medicine 1989 Jul;87;93-4 1989 Jul
Necrotizing vasculitis associated with diphenylhydantoin: two fatal cases.
Human pathology 1983 Feb;14;182-4 1983 Feb

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