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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Phenylephrine

2

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary edema following instillation of topical phenylephrine eyedrops in a child under general anesthesia.
European journal of ophthalmology 2011;21;115-7 2011
Pulmonary oedema following topical phenylephrine administration in a child anaesthetised for cataract extraction.
Paediatric anaesthesia 2009 Feb;19;181-2 2009 Feb
Acute pulmonary edema due to phenylephrine injection in patient receiving long-term beta-blocker therapy: A case report.
Korean journal of anesthesiology 2009 Aug;57;242-245 2009 Aug
Acute pulmonary edema caused by epoprostenol infusion in a child with scimitar syndrome and pulmonary hypertension.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2003 Jan;4;111-4 2003 Jan
Intraoperative pulmonary oedema in a child following systemic absorption of phenylephrine eyedrops.
British journal of anaesthesia 2002 Mar;88;440-2 2002 Mar
Management of intraoperative pulmonary oedema in a child following systemic absorption of phenylephrine eyedrops.
British journal of anaesthesia 2002 Aug;89;343; author reply 343-4 2002 Aug
Systemic reaction to subconjunctival phenylephrine.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 1978 Oct;13;290-3 1978 Oct

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