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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nonsteroidal anti-inflammatory drugs (NSAIDs)

5

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 13/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aspirin (Salicylate-ASA) - Aspirin containing drugs
5
Celecoxib
2
Diclofenac
2
Fenbufen
1
Fenoprofen
1
Ibuprofen
3
Ketoprofen
1
Ketorolac
1
Loxoprofen
1
Mefenamic acid
1
Meloxicam
1
Naproxen
2
Oxyphenbutazone
1
Phenylbutazone
2
Piroxicam
1
Pranoprofen
1
Propafenone
1

Publications

Angiotensin-Converting Enzyme Inhibitors and Other Medications Associated With Angioedema.
Cureus 2023 Nov;15;e49306 2023 Nov
Acute angioedema in Cape Town emergency centres and a suggested algorithm to simplify and improve management.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2023 Aug 03;113;51-57 2023 Aug 03
Angioedema and emergency medicine: From pathophysiology to diagnosis and treatment.
European journal of internal medicine 2019 Jan;59;8-13 2019 Jan
Drug-induced angioedema: experience of Italian emergency departments.
Internal and emergency medicine 2014 Jun;9;455-62 2014 Jun
Prognostic factors in outcome of angioedema in the emergency department.
Allergy and asthma proceedings 2014;35;362-70 2014
NSAID-sensitive antihistamine-induced urticaria/angioedema.
Journal of investigational allergology & clinical immunology 2011;21;488-90 2011
Risk of hospitalization for angio-oedema among users of newer COX-2 selective inhibitors and other nonsteroidal anti-inflammatory drugs.
British journal of clinical pharmacology 2006 Oct;62;496-501 2006 Oct
Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2005 Aug;95;154-8 2005 Aug
Epidemiological study of angioedema and ACE inhibitors.
Australian and New Zealand journal of medicine 1996 Dec;26;777-82 1996 Dec
Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations.
European journal of clinical pharmacology 1994;47;297-303 1994

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