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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pergolide

3

V.c Pleural thickening - Fibrothorax

2
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.
Archives of neurology 2005 Aug;62;1290-5 2005 Aug
Diagnosis and management of pergolide-induced fibrosis.
Movement disorders : official journal of the Movement Disorder Society 2004 Jun;19;699-704 2004 Jun
Fibrosis associated with dopamine agonist therapy in Parkinson's disease.
Clinical neuropharmacology 2003;26;109-11 2003
Pergolide-induced pleuropulmonary fibrosis.
Clinical neuropharmacology 2002;25;290-3 2002
Pleuropulmonary disease due to pergolide use for restless legs syndrome.
Chest 2001 Jul;120;313-6 2001 Jul
Pericardial, retroperitoneal, and pleural fibrosis induced by pergolide.
Journal of neurology, neurosurgery, and psychiatry 1999 Jan;66;79-81 1999 Jan

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