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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pergolide

3

XII.k Constrictive pericarditis - Pericardial thickening

1
Last update : 24/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.
Archives of neurology 2005 Aug;62;1290-5 2005 Aug
Chronic pericardial constriction linked to the antiparkinsonian dopamine agonist pergolide.
Postgraduate medical journal 2002 Jan;78;49-50 2002 Jan
Pericardial, retroperitoneal, and pleural fibrosis induced by pergolide.
Journal of neurology, neurosurgery, and psychiatry 1999 Jan;66;79-81 1999 Jan

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