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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pentamidine

2

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Aerosolized pentamidine as alternative primary prophylaxis against Pneumocystis carinii pneumonia in adult hepatic and renal transplant recipients.
Chest 1996 May;109;1250-5 1996 May
Long-term administration of aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia in infants and children with symptomatic human immunodeficiency virus infection. The Italian Pediatric Collaborative Study Group on Pentamidine.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996 Jun 01;12;158-63 1996 Jun 01
Aerosolized pentamidine for the prevention of Pneumocystis carinii pneumonia in children with cancer intolerant or allergic to trimethoprim/sulfamethoxazole.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994 Feb;12;258-61 1994 Feb
High incidence of bronchospasm with regular administration of aerosolized pentamidine.
Chest 1992 Jan;101;79-81 1992 Jan
Intravenous pentamidine-induced bronchospasm.
Chest 1992 Dec;102;1891-2 1992 Dec
Acute pulmonary effects of aerosolized pentamidine. A randomized controlled study. Toronto Aerosolized Pentamidine Study (TAPS) Group.
Chest 1990 Oct;98;907-10 1990 Oct

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