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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pentamidine

2

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1
Last update : 08/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pentamidine-induced torsades de pointes.
The Annals of pharmacotherapy 1994 Feb;28;282-3 1994 Feb
Pentamidine-induced torsades de pointes.
The Pediatric infectious disease journal 1993 Aug;12;692-4 1993 Aug
Prolonged recurrence of pentamidine-induced torsades de pointes.
The Annals of pharmacotherapy 1992 Nov;26;1365-9 1992 Nov
Pentamidine-induced cardiotoxicity.
Israel journal of medical sciences 1990 Oct;26;588-9 1990 Oct
Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity.
Chest 1988 Dec;94;1303-6 1988 Dec

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