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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

X.ac Anti-GBM antibody disease (Goodpasture-like or flare of preexisting GS)

1
Last update : 29/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

D-Penicillamine-induced Goodpasture's-like syndrome in primary biliary cirrhosis--successful treatment with plasmapheresis and immunosuppressives.
Gastroenterology 1980 May;78;1046-9 1980 May
D-penicillamine induced Goodpasture's syndrome in Wilson's disease.
Annals of internal medicine 1975 May;82;673-6 1975 May

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