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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

XV.z Path: Obliterative (constrictive) bronchiolitis (see also IVc, IVn)

1
Last update : 26/01/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Obliterating bronchiolitis in a patient treated with (D)-penicillamine.
Archivos de bronconeumologia 2013 Sep;49;411-2 2013 Sep
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine.
The European respiratory journal 1996 Jun;9;1317-9 1996 Jun
Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the use of penicillamine.
JAMA 1979 Aug 10;242;528-32 1979 Aug 10

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