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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

IV.n Obstructive airway dysfunction (see also IVc, XVx)

2
Last update : 27/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Obliterating bronchiolitis in a patient treated with (D)-penicillamine.
Archivos de bronconeumologia 2013 Sep;49;411-2 2013 Sep
Beneficial effect of intravenous cyclophosphamide and oral prednisone on D-penicillamine-associated bronchiolitis obliterans.
Arthritis and rheumatism 1985 Jan;28;93-7 1985 Jan
Upper and lower airway disease in penicillamine treated patients with rheumatoid arthritis.
The Journal of rheumatology 1983 Jun;10;406-10 1983 Jun
[The respiratory complications of D-Penicillamine therapy (author's transl)].
Revue francaise des maladies respiratoires 1982;10;7-20 1982

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