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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A Pediatric Case of a D-Penicillamine Induced ANCA-associated Vasculitis Manifesting a Pulmonary-Renal Syndrome.
Journal of Korean medical science 2019 Jun 24;34;e173 2019 Jun 24
D-penicillamine-induced ANA (+) ANCA (+) vasculitis in pediatric patients with Wilson's disease.
Clinical nephrology 2016 May;85;296-300 2016 May
ANCA-associated Goodpasture's syndrome in a patient with rheumatoid arthritis on penicillamine.
Indian journal of nephrology 2012 Jan;22;45-7 2012 Jan
D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 Nov;50;821-5 2007 Nov
Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.
Arthritis and rheumatism 2000 Feb;43;405-13 2000 Feb
Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995 Oct;10;1925-8 1995 Oct

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