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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 17/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

D-penicillamine-induced acute hypersensitivity pneumonitis and cholestatic hepatitis in a patient with rheumatoid arthritis.
Clinical and experimental rheumatology 1985;3;337-9 1985
Relationship of gold and penicillamine therapy to diffuse interstitial lung disease.
Annals of the rheumatic diseases 1981 Apr;40;136-41 1981 Apr

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