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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Para-aminosalicylic acid (PAS)

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 08/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Drug-induced eosinophilic pneumonia: high-resolution CT findings in 14 patients.
AJR. American journal of roentgenology 2006 Feb;186;368-73 2006 Feb
The lung in inflammatory bowel disease.
Medicine 1993 May;72;151-83 1993 May
Loeffler's syndrome due to paraaminosalicylic acid.
Diseases of the chest 1962 Jul;42;100-3 1962 Jul
Complications in the chemotherapy of tuberculosis. A review with analysis of the experience of 3,148 patients.
The American review of respiratory disease 1961 Mar;83;359-71 1961 Mar
Lung infiltrations as a complication of PAS treatment.
Tubercle 1958 Jun;39;169-71 1958 Jun
Allergic (Löffler's) pneumonitis occurring during antituberculous chemotherapy; report of three cases.
American review of tuberculosis 1956 Sep;74;445-53 1956 Sep
Allergic pneumonitis during chemotherapy for tuberculosis: report of two cases due to paraaminosalicylic acid.
Annals of internal medicine 1955 Jan;42;190-7 1955 Jan
Löffler's reaction to para-aminosalicylic acid.
American review of tuberculosis 1954 Jul;70;171-5 1954 Jul
Allergic reactions to para-aminosalicylic acid; report of seven cases, including one case of Löffler's syndrome.
American review of tuberculosis 1952 Mar;65;235-49 1952 Mar

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