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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Paclitaxel

5

XV.h Path: NSIP-fibrotic pattern

1
Last update : 21/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16 Suppl 1;391-3 2006

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