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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Nitrosoureas (suffixes '-NU', '-mustine')
4
VI.c
Pulmonary veno-occlusive disease
1
Last update :
31/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
See also under
Bendamustine
Carmustine (BCNU)
Fotemustine
Lomustine (CCNU)
Ranimustine
Semustine (methyl-CCNU)
Publications
Pulmonary veno-occlusive disease following therapy for malignant neoplasms.