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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrosoureas (suffixes '-NU', '-mustine')

4

I.b Pneumonitis (ILD)

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bendamustine
1
Carmustine (BCNU)
3
Fotemustine
1
Lomustine (CCNU)
3
Ranimustine
1
Semustine (methyl-CCNU)
1

Publications

Pulmonary toxicity of lomustine.
Cancer treatment reports 1987;71;786-7 1987
Pulmonary toxicity in long-term administration of BCNU.
Cancer treatment reports 1976 Nov;60;1691-4 1976 Nov

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