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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

XI.c Pleuritic chest pain

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Recurrent acute nitrofurantoin-induced pulmonary toxicity.
Pharmacotherapy 2006 May;26;713-8 2006 May
Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
The Annals of pharmacotherapy 2004 Apr;38;612-6 2004 Apr
Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.
Obstetrical & gynecological survey 1996 Jun;51;367-70 1996 Jun
Hospitalizations for pulmonary reactions following nitrofurantoin use.
Chest 1989 Sep;96;512-5 1989 Sep

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