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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pleural effusion: An uncommon manifestation of nitrofurantoin-induced pulmonary injury.
Respiratory medicine case reports 2016;19;65-7 2016
Nitrofurantoin pulmonary toxicity: neglected threat.
Current drug safety 2010 Apr;5;125-8 2010 Apr
Eosinophilic pleural effusions.
Current opinion in pulmonary medicine 2003 Jul;9;254-60 2003 Jul
Lymphopenia in acute nitrofurantoin pleuropulmonary reactions.
The Journal of allergy and clinical immunology 1977 Jun;59;445-8 1977 Jun
Nitrofurantoin pneumonia.
JAMA 1967 Mar 06;199;765-6 1967 Mar 06

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