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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Adverse reactions to nitrofurantoin in the United Kingdom, Sweden, and Holland.
British medical journal (Clinical research ed.) 1982 May 15;284;1440-2 1982 May 15
[Asthma and nitrofurantoin].
Revista clinica espanola 1979 Feb 15;152;235-7 1979 Feb 15
Nitrofurantoin pulmonary hypersensitivity.
The Medical journal of Australia 1970 Jul 18;2;136-9 1970 Jul 18
Asthma associated with the use of nitrofurantoin.
Canadian Medical Association journal 1966 Jan 01;94;40-1 1966 Jan 01
Allergic tracheobronchitis due to nitrofurantoin sensitivity. Report of a case.
Diseases of the chest 1965 Oct;48;429-30 1965 Oct

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