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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

II.b ARDS - Acute lung injury

1
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Nitrofurantoin-induced pulmonary reaction involving respiratory symptoms: case report.
The Canadian journal of hospital pharmacy 2011 Sep;64;362-5 2011 Sep
[Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].
Revista portuguesa de pneumologia 2004;10;355-64 2004
Adult respiratory distress syndrome associated with acute nitrofurantoin toxicity. Successful treatment with continuous positive airway pressure.
Respiration; international review of thoracic diseases 1980;39;318-22 1980

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