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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

2
Last update : 01/09/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Nitrofurantoin-induced pulmonary reaction involving respiratory symptoms: case report.
The Canadian journal of hospital pharmacy 2011 Sep;64;362-5 2011 Sep
Nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia: report of a case.
Canadian respiratory journal 2008 Sep;15;311-2 2008 Sep
Bronchiolitis interstitial pneumonitis: a pathologic study of 31 lung biopsies with features intermediate between bronchiolitis obliterans organizing pneumonia and usual interstitial pneumonitis, with clinical correlation.
Annals of diagnostic pathology 2008 Jun;12;171-80 2008 Jun
Drug-associated organizing pneumonia: high-resolution CT findings in 9 patients.
Journal of thoracic imaging 2006 Mar;21;22-6 2006 Mar

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