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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

2
Last update : 01/09/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Nitrofurantoin-induced pulmonary toxicity: A case report and review of the literature.
Journal of infection and public health 2015;8;309-13 2015
Nitrofurantoin: cause of DRESS syndrome.
BMJ case reports 2013 May 08;2013; 2013 May 08
Nitrofurantoin-induced immune-mediated lung and liver disease.
Vojnosanitetski pregled 2012 Jun;69;536-40 2012 Jun
Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2008 Mar;34;181-4 2008 Mar
[Drug-induced eosinophilic pneumonia].
Der Nervenarzt 2008 Jun;79;696-8 2008 Jun
[Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].
Revista portuguesa de pneumologia 2004;10;355-64 2004
Two unusual pathological reactions to nitrofurantoin: case reports.
Histopathology 1986 Jul;10;701-6 1986 Jul

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