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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

1
Last update : 27/10/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Reversible lung fibrosis in a 6-year-old girl after long term nitrofurantoin treatment.
BMC pulmonary medicine 2020 Nov 26;20;313 2020 Nov 26
Downstaging of Non-Small-Cell Lung Cancer Through Identification of Reversible Drug Toxicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016 Jan 10;34;e6-8 2016 Jan 10
Nitrofurantoin-induced alterations in pulmonary tissue. A report on five patients with acute or subacute reactions.
Acta pathologica et microbiologica Scandinavica. Section A, Pathology 1977 Sep;85;713-20 1977 Sep

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