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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

V.i Pleuritis (can cause chest pain)

4
Last update : 01/09/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Nitrofurantoin pulmonary toxicity: neglected threat.
Current drug safety 2010 Apr;5;125-8 2010 Apr
Recurrent acute nitrofurantoin-induced pulmonary toxicity.
Pharmacotherapy 2006 May;26;713-8 2006 May
Hospitalizations for pulmonary reactions following nitrofurantoin use.
Chest 1989 Sep;96;512-5 1989 Sep
Pulmonary reactions to nitrofurantoin. 447 cases reported to the Swedish Adverse Drug Reaction Committee 1966-1976.
European journal of respiratory diseases 1981 Jun;62;180-9 1981 Jun
[Acute allergic pulmonary reaction following use of nitrofurantoin].
Nederlands tijdschrift voor geneeskunde 1980 May 10;124;751-5 1980 May 10
Pleuropneumonic reactions to nitrofurantoin.
The New England journal of medicine 1969 Nov 13;281;1087-90 1969 Nov 13
Acute pulmonary sensitivity to nitrofurantoin.
The American journal of roentgenology, radium therapy, and nuclear medicine 1968 Dec;104;784-6 1968 Dec
Nitrofurantoin pneumonia.
JAMA 1967 Mar 06;199;765-6 1967 Mar 06
Pulmonary reactions simulating cardiac pulmonary edema caused by nitrofurantoin.
The New England journal of medicine 1965 Nov 25;273;1185-7 1965 Nov 25
PLEUROPULMONARY REACTION TO NITROFURANTOIN.
JAMA 1964 Jul 20;189;239-40 1964 Jul 20

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