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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Naloxone

2

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Opiates - Opioids - Opium
5

Publications

Pulmonary edema after naloxone administration for opioid reversal: a systematic review of case reports and causality assessment using the Naranjo scale.
Clinical toxicology (Philadelphia, Pa.) 2024 May;62;334-342 2024 May
Non-Cardiogenic Pulmonary and Peripheral Edema as an Untoward Reaction of Naloxone.
Journal of addictions nursing 2024 Apr-Jun 01;35;114 2024 Apr-Jun 01
The Double-Edged Sword: Naloxone-Induced Noncardiogenic Pulmonary Edema.
Cureus 2023 Jul;15;e41642 2023 Jul
Naloxone-Induced Acute Pulmonary Edema is Dose-Dependent: A Case Series.
The American journal of case reports 2021 Mar 17;22;e929412 2021 Mar 17
Naloxone induced pulmonary edema.
Journal of community hospital internal medicine perspectives 2021 Jan 26;11;139-142 2021 Jan 26
Naloxone-Induced Noncardiogenic Pulmonary Edema.
American journal of therapeutics 2020;27;e672-e673 2020
Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report.
Drug safety - case reports 2018 May 10;5;20 2018 May 10
[Naloxone-induced pulmonary edema. Case report with review of the literature and critical evaluation].
Der Anaesthesist 2012 Feb;61;129-36 2012 Feb
Naloxone-induced pulmonary edema: a potential cause of postoperative morbidity in laparoscopic donor nephrectomy.
Indian journal of medical sciences 2009 Feb;63;72-5 2009 Feb
Naloxone--for intoxications with intravenous heroin and heroin mixtures--harmless or hazardous? A prospective clinical study.
Journal of toxicology. Clinical toxicology 1996;34;409-16 1996
Two cases of naloxone-induced pulmonary oedema--the possible use of phentolamine in management.
Anaesthesia and intensive care 1991 Nov;19;578-80 1991 Nov
Naloxone-induced pulmonary edema.
Annals of emergency medicine 1987 Nov;16;1294-6 1987 Nov
Pulmonary edema following low-dose naloxone administration.
Anesthesiology 1986 Dec;65;709-10 1986 Dec
Acute pulmonary edema in healthy teenagers following conservative doses of intravenous naloxone.
Anesthesiology 1984 May;60;485-6 1984 May
Pulmonary edema following naloxone administration in a patient without heart disease.
Anesthesiology 1983 Dec;59;576-7 1983 Dec
Acute pulmonary edema following naloxone reversal of high-dose morphine anesthesia.
Anesthesiology 1977 Oct;47;376-8 1977 Oct

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