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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Morphine

5

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

4
Last update : 31/05/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Codeine
3
Opiates - Opioids - Opium
5
Rachacha (so-called)
1

Publications

The effect of acute morphine on obstructive sleep apnoea: a randomised double-blind placebo-controlled crossover trial.
Thorax 2019 Feb;74;177-184 2019 Feb
Non-analgesic effects of opioids: opioid-induced respiratory depression.
Current pharmaceutical design 2012;18;5994-6004 2012
Morphine and its metabolites after patient-controlled analgesia: considerations for respiratory depression.
Journal of clinical anesthesia 2011 Mar;23;102-6 2011 Mar
Safety of morphine in nonintubated infants in the neonatal intensive care unit.
The Clinical journal of pain 2009 Jun;25;418-22 2009 Jun
Long-term respiratory depression induced by intrathecal morphine treatment for chronic neuropathic pain.
Anesthesiology 2006 Aug;105;431-3 2006 Aug
Effects of intrathecal morphine on the ventilatory response to hypoxia.
The New England journal of medicine 2000 Oct 26;343;1228-34 2000 Oct 26
Time course of changes in breathing pattern in morphine- and oxycodone-induced respiratory depression.
Anaesthesia 1999 Sep;54;835-40 1999 Sep
Morphine-induced ventilatory failure after spinal cord compression.
Journal of pain and symptom management 1999 Aug;18;140-2 1999 Aug
Acute respiratory depression as a complication of nebulised morphine.
Canadian journal of anaesthesia = Journal canadien d'anesthesie 1998 Jan;45;60-2 1998 Jan

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