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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin C

3

II.c ARDS and the hemolytic-uremic syndrome (HUS)

2
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Cancer-associated hemolytic-uremic syndrome: analysis of 85 cases from a national registry.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989 Jun;7;781-9 1989 Jun
A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.
Cancer 1986 Oct 01;58;1428-36 1986 Oct 01
Microangiopathic hemolytic anemia, renal failure, and noncardiogenic pulmonary edema: a chemotherapy-induced syndrome.
Cancer treatment reports 1983 May;67;429-34 1983 May

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