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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin C

3

II.b ARDS - Acute lung injury

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC.
World journal of surgical oncology 2017 Feb 20;15;49 2017 Feb 20
Intravesical mitomycin-C-induced interstitial pneumonia.
Respiration; international review of thoracic diseases 2010;80;256-9 2010
Mitomycin lung toxicity. Acute and chronic phases.
American journal of clinical oncology 1997 Jun;20;282-4 1997 Jun
A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.
Cancer 1986 Oct 01;58;1428-36 1986 Oct 01
Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.
Archives of internal medicine 1985 Oct;145;1905-7 1985 Oct
Combination chemotherapy with doxorubicin and mitomycin C in non-small cell bronchogenic carcinoma. Severe pulmonary toxicity from q 3 weekly mitomycin C.
American journal of clinical oncology 1984 Dec;7;719-24 1984 Dec
Pulmonary toxicity of mitomycin.
Cancer 1980 Jan 15;45;236-44 1980 Jan 15
Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin C.
Cancer 1979 May;43;1598-603 1979 May

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