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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin C

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A prospective study of pulmonary function in patients receiving mitomycin.
Chest 1996 Apr;109;939-44 1996 Apr
Pulmonary toxicity induced by mitomycin C is highly responsive to glucocorticoids.
Cancer 1986 Jun 15;57;2285-90 1986 Jun 15
Mitomycin C and vindesine associated pulmonary toxicity with variable clinical expression.
Cancer 1985 Feb 01;55;542-5 1985 Feb 01
Pulmonary toxicity of mitomycin.
Cancer 1980 Jan 15;45;236-44 1980 Jan 15

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