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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Mitomycin C
3
I.a
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
2
Last update :
31/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
A prospective study of pulmonary function in patients receiving mitomycin.
Pulmonary toxicity induced by mitomycin C is highly responsive to glucocorticoids.
Mitomycin C and vindesine associated pulmonary toxicity with variable clinical expression.
Pulmonary toxicity of mitomycin.