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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin C

3

VI.c Pulmonary veno-occlusive disease

1
Last update : 25/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Characteristics and Long-term Outcomes of Pulmonary Venoocclusive Disease Induced by Mitomycin C.
Chest 2021 Mar;159;1197-1207 2021 Mar
Lung transplantation for mitomycin-induced pulmonary veno-occlusive disease.
Presse medicale (Paris, France : 1983) 2017 Dec;46;1223-1225 2017 Dec
Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models.
Circulation 2015 Sep 01;132;834-47 2015 Sep 01
Pulmonary veno-occlusive disease after neoadjuvant mitomycin chemotherapy and surgery for lung carcinoma.
Lung cancer (Amsterdam, Netherlands) 2002 May;36;213-5 2002 May
Pulmonary veno-occlusive disease after chemotherapy.
Human pathology 1983 Jan;14;88-91 1983 Jan

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