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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methysergide

2

V.c Pleural thickening - Fibrothorax

1
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ergots, ergot alkaloids, ergolines
4

Publications

[Pleural fibrosis as a side effect of years-long methysergide therapy].
Deutsche medizinische Wochenschrift (1946) 1991 Sep 20;116;1433-6 1991 Sep 20
Pleural thickening caused by Sansert and Ergotrate in the treatment of migraine.
AJR. American journal of roentgenology 1980 Aug;135;375-7 1980 Aug
Fibrotic disorders associated with methysergide therapy for headache.
The New England journal of medicine 1966 Feb 17;274;359-68 1966 Feb 17

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