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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Methysergide
2
V.a
Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
1
Last update :
10/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ergots, ergot alkaloids, ergolines
Publications
[Pleuro-pulmonary fibrosis caused by methysergide].
Pleural thickening caused by Sansert and Ergotrate in the treatment of migraine.
Pleural effusion and fibrosis secondary to Sansert administration.
Pleural effusion and fibrosis during treatment with methysergide.