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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methysergide

2

XII.k Constrictive pericarditis - Pericardial thickening

1
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
See also under
Ergots, ergot alkaloids, ergolines
4

Publications

An unusual side-effect of long-term methysergide treatment.
Australian and New Zealand journal of medicine 1995 Apr;25;171 1995 Apr
Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy.
Journal of the American College of Cardiology 1984 Jul;4;196-9 1984 Jul
Methysergide therapy and constrictive pericarditis.
Annals of internal medicine 1978 Feb;88;213-4 1978 Feb
Constrictive pericarditis due to methysergide therapy.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1976 Sep 25;50;1595-7 1976 Sep 25
Fibrotic disorders associated with methysergide therapy for headache.
The New England journal of medicine 1966 Feb 17;274;359-68 1966 Feb 17

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